DISAPPEARANCE OF THE ANASAZI Research Paper Example | Topics and Well Written Essays - 2250 words

DISAPPEARANCE OF THE ANASAZI - Research Paper Example History portrays that they were generally quite peaceful people who survived through trade and farming. Even so, the Anasazi later disappeared, causing many varied academic postulations. Various theories, such as climate change theories, religious theories, and cannibalism theory suggest different reasons for their disappearance. Climate change theories postulate that climatic changes led to the area receiving unreliable rainfall causing the community to leave. Drought theory postulates that the 1276-199. On the other hand, religious theories point out that certain religious practices must have been responsible for the disappearance of the Anasazi. Cannibalism theory asserts possible existence of a cannibal group is likely to have contributed to the disappearance of the Anasazi. All theories contribute to the understanding of the Anasazi. Disappearance of the Anasazi For a long time, major aspects of southwestern archaeology have continued to perplex many people. Despite the fact tha t there have been various theories that have substantially attempted to unravel the mystery behind the disappearance of the Anasazi, one may observe that even the most acceptable explanations remain largely postulations. Of course any reasonable person would ask why a community of people who live so peacefully could just abandon their civilizations and head into the unknown. Certainly there could be more than archaeology and other historical reconstruction methods may offer towards the explanation of the disappearance of the Anasazi (Catherine and Duff 2008). Even so, one may observe that quite substantial information about the Anasazi have been unraveled, thanks to historians. It appears that an understanding of the theories of disappearance of the Anasazi people cannot be sufficiently told without making efforts to understand the efforts their way of life. Understanding the way of life of the Anasazi will help in understanding how their society perceived life in its various dimens ions. Doing so enables one to assess and critique various theories that attempt to explain the disappearance of the Anasazi. This is because it could be that probably more than one theory can sufficiently and convincingly explain the disappearance of the Anasazi people. For the purposes of this paper, this paper shall briefly visit bring into light the organization of the Anasazi before proceeding to analyze the theories that make an effort to explain the disappearance of the Anasazi people (Peter 2004). Background History of the Anasazi Historical records have indicated that the Anasazi people had inhabited the vast plateaus of the American Southwest. They had adapted to the harsh climate and thrived in the sun-scorched mesas and cliffs. They occupied what one may observe as the current ruins of Mesa Verde, Chaco Canyon, and Canyon de Chelly. The remains still reveal a powerful evidence of a civilization that one may refer to as advanced given its time in history. It is intriguing to observe that much as the Anasazi do not any association with the Navajo people although the word Anasazi is a Navajo word. In fact the Navajo people just refer to them in what translates as â€Å"those before us† or in other translations as â€Å"ancient strangers.† This implies a missing link with other civilizations. They are likely not to have interacted with other civilizations; no wonder there has been no archaeological evidence of any weapons (Peter 2004). Assessment of the emergence of the Anasazi is found in the old legends. Although one must note well in advance that the origins of the Anasazi remain a mystery almost just as much as their disappearance. Even so, it is still vital to highlight that constructed legends have it that the original Anasazi had come out of the lower world

Swot Analysis Company Essay Example for Free

Swot Analysis Company Essay 4. SWOT Analysis The overall evaluation of a company’s Strengths(S), Weaknesses (W), Opportunities (O) and Threats (T) is called SWOT Analysis. It is a way of monitoring the external and internal marketing environment. 4.1. Analysis of Strengths and Weaknesses This analyses the internal environment of a company. According to our comprehensive observation and analysis, the following Strengths and Weaknesses of Mini Co-op city are identified. 4.1.1. Strengths †¢ As the cost of living is relatively high, this cater to low income earners by providing commodities at controlled prices, which results in lesser price fluctuations. †¢ Samurdhi beneficiaries receive stamps of Rs.240, Rs.340, Rs.540 per month to purchase commodities. 4.1.2. Weaknesses †¢ Lack of parking facilities. †¢ The name board is not attractive and eye catching. †¢ Arrangement of goods and layout is ineffective. †¢ Display has not been utilized in correct manner and the eye level shelves are empty. †¢ They are practicing the sales oriented concept, not the marketing oriented concept. †¢ No marketing and promotional effort. †¢ Lack of staff and currant members are not enthusiastic. †¢ The place in which outlets are located is not convenient. 4.2. Analysis of Opportunities and Threats This analyses the external environment of a company. According to our observations, we identified following Opportunities and Threats of Mini co-op city. 4.2.1. Opportunities †¢ Existence of a network of branches and opportunity to further expand it through government fund allocation. †¢ With terrorism coming to an end and achievement of peace, ability to capture new North and Eastern market which attracts relatively low competition. 4.2.2. Threats †¢ Limited availability of funds. †¢ High political influence and change of political parties will affect entire policies and practices. †¢ Higher competition faced retail sellers and well organized chain of supermarket

Role of Dietary Intervention in Ameliorating Disability

Role of Dietary Intervention in Ameliorating Disability The Role of Dietary Intervention in Ameliorating Disability Experienced by Multiple Sclerosis Patients Mark M. Makar Hypothesis: Diet modification can significantly improve disability and quality of life in multiple sclerosis patients. Abstract (word count: 213) Hypothesis: Diet modification can significantly improve disability and quality of life in multiple sclerosis patients. Methods: The PubMed database was searched on January 18, 2017 to identify studies relevant to this review. The database search combined terms from three themes: 1) multiple sclerosis patients 2) diet and 3) diet modification. This search yielded 118 articles for screening, with no duplicates. With abstract screening and inclusion criteria, 10 articles were included in this final review. Results: Modifying the diet of multiple sclerosis patients can greatly reduce fatigue and moderately help decrease symptoms experienced during this disease. Replacing animal based protein and saturated fatty acids from the diet, with plant-based alternatives that are high in starch showed noticeable improvement in symptoms experienced by multiple sclerosis patients. The plant based diet showed a decrease in inflammatory cells, damage of the blood brain barrier, demyelination, as well as axonal and oligodendrocyte injury. Conclusions: A variety of dietary modifications have been demonstrated to effectively improve quality of life and reduce disability in patients suffering from multiple sclerosis. More studies are needed to assess the efficacy of dietary intervention with respect to reducing episodes of disability experienced by multiple sclerosis patients and including diet modification into the current disease modifying therapies available. Key Words: multiple sclerosis, diet modification, review Ultramini Abstract: A search of the PubMed database yielded 10 articles for review. A variety of randomized controlled trials, cohort studies, case studies, cross sectional studies, and surveys regarding multiple sclerosis patients and diet modification to exclude animal protein from the diet and include only a plant based diet, can help to ameliorate disability. Introduction Multiple Sclerosis has an ongoing prevalence of 33% globally, with its incidence growing in North America and Europe (Evans C et al., 2013). Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. It is the number one cause of non-traumatic neurodegenerative disability in the young adult population, and is twice as common in women as men (Browne, P et al., 2014). The etiology of multiple sclerosis is still unknown; however, it is believed to have autoimmune origins. Patients tend to experience multiple sclerosis differently; the most common presenting symptoms include sensory (40%), motor (39%), fatigue (30%), and visual (30%), and urinary incontinence (17%) along with less common symptoms presenting as pain and cognitive decline (Evans C et al., 2013). The wide array of symptoms experienced in multiple sclerosis has sprung forth an influx of scholarly research on beneficial disease- modifying therapies (DMTs) and alternative non-traditional methods for treating multiple sclerosis. Many governments across the world subsidize the current platform therapies for multiple sclerosis across the world including interferon-beta and/ or glatiramer acetate (Browne, P et al., 2014). There is a considerable degree of variance between different levels of income groups in society with regards to accessibility of government-funded therapies for multiple sclerosis (Browne, P et al., 2014). Availability of government funded DMTs were accessible to 96% of high-income countries, 45% of lower to middle income countries, and none in the low-income countries (Browne, P et al., 2014). These surprising statistics have led to new research development, which focus on new treatment methods for multiple sclerosis that cannot only be efficacious, but also be economically accessible for all levels of socioeconomic statuses across the world. There is much speculation regarding cost effectiveness of current treatment regiments for multiple sclerosis with interferon-beta and/ or glatiramer ace tate. There is a common consensus that the current platform therapies are not cost effective for the long-term therapy of multiple sclerosis (Bogglid, M et al., 2009). Given the pathology of multiple sclerosis, it is believed that dietary factors play a key role in autoimmune degradation and can induce myelin breakdown in the central nervous system by molecular mimicry (Ashtari, F et al., 2015). Multiple sclerosis prevalence is believed to be high in regions furthest away from the equator, however recent research has found that these regions of the world also consume a greater amount of saturated fat and animal protein such as dairy (Swank, R et al., 1990). Diets high in animal protein saturated fatty acids tend to worsen progression of multiple sclerosis and increase relapse of symptoms (Hadgkiss, E et al., 2015).It has been proposed that dietary interventions such as low fat, plant-based diet may decrease autoimmune inflammation in the central nervous system and help maintain the protective integrity of the blood brain barrier (Riccio, P et al., 2016). Dietary modifications are thought to be both a cost effective and efficacious treatment option for mitigating symptoms experienced by multiple sclerosis patients such as loss of motor and or sensory function, as well as fatigue (Yadav, V et al., 2016). This paper aims to provide a practical overview of recent scholarly literature in order to answer the research question: Does diet modification significantly decrease the level of disability and improve the quality of life in patients suffering from multiple sclerosis? The review will be guided under the hypothesis: diet modification can significantly improve disability and quality of life in patients suffering with multiple sclerosis. Methods Articles about multiple sclerosis and diet modification were searched on January 19, 2017 using the databases Pub Med and Google Scholar. The database search combined terms from three themes: 1) multiple sclerosis patients (relapsing remitting multiple sclerosis OR primary progressive multiple sclerosis OR multiple sclerosis OR central nervous system demyelination OR autoimmune encephalomyopathy OR demyelinating disease 2) diet (food OR animal protein OR vegan diet OR plant based diet) and 3) diet modification (meal plan OR starch based diet). When searching for articles, screening settings were set to be within 10 years, English language, full text articles, review, meta-analysis, randomized control trials, and clinical trials. Boolean operators used were OR and AND; OR was used to extract specific terms from the three main themes. AND was used to connect the three themes used in this review. This search yielded 118 articles for screening, with no duplicates. With abstract screening and inclusion criteria, 10 articles were included in this final review. Inclusion Criteria All the articles used in this systemic review had to meet the following criteria: 1) English 2) patients with multiple sclerosis for at least 6 months 3) diet modification/ assesment or pharmacological treatment as intervention. The term multiple sclerosis was defined as patients showing symptoms for at least 6 months and diet modification was defined as any change in daily food intake. Exclusion Criteria Articles were excluded from the review if they were published prior to 2007 and/or were not written in the English language and/or if patients had any type of prior chronic disease other than multiple sclerosis. Results Randomized Controlled Studies In a randomized controlled study by Vijayshree Yadav et al, 61 patients with relapsing remitting multiple sclerosis were monitored for a one-year period. The participants were randomly allocated into two groups: Diet group and control group. The diet group was placed on a strict starch plant based diet (potatoes, corn, beans, bread, sweet potato and rice), while the control group was allowed to continue with their usual diet (meat, eggs, dairy products, fish) throughout the study. Each participant was surveyed once every three months or the duration of the study during which disability, and fatigue levels were recorded (by the expanded disability status scale, EDSS and fatigue severity scale, FSS/ modified fatigue impact scale, MFIS respectively). Serum lipid levels and brain MRI were also recorded at the end of the twelve months. The results observed demonstrated a significant reduction (pFigure 1 shows a summary of fatigue improvement throughout the duration of the study. These fin dings suggest that intervention with a plant-based diet does indeed help reduce fatigue in multiple sclerosis patients. Figure 1: Graph of Fatigue Scores as Measured by FSS score (A) and MFIS score (B) over a 12 Month Time Span In a similar randomized control trial by Anja Mahler et al, 18 patients with relapsing remitting multiple sclerosis were randomly divided into two groups. The intervention group was started on 600 mg green tea catechin capsule per day and the control group received a placebo capsule for 12 weeks. A 4-week period was allotted during crossover to assure a sufficient wash out period. The results observed determined there was a significant increase in efficiency of muscle work from 20 (SD= 3) in the placebo group to 25 (SD= 6) in the intervention group (p>0.004). This finding suggests that intervention with plant based green tea extract helps to decrease muscle fatigue in multiple sclerosis patients. Cohort and Cross Sectional Studies: Emily Hadgkiss et al surveyed 2087 patients with multiple sclerosis globally. The comprehensive online survey inquired about dietary habits, quality of life, disability, and relapse rate. Dietary habits were assessed using the Diet Habits Questionnaire (DHQ), baseline quality of life was calculated using the Multiple Sclerosis Quality of Life scale (MSQOL-54), and disability was calculated by using the Expanded Disability Status Scale (EDSS). Results of this study demonstrated that patients who reported higher intake of fruits and vegetables and low intake of fats had significantly higher physical health scores (PHC) ranging from 54 to 68 (pFigure 2 and Figure 3 shows a brief summary of these results. Figure 2: Mean Physical Health Composite by Dietary Factors   Ã‚   Figure 3: Mean Mental Health Composite by Dietary Factors Another significant finding in this study showed that patients who consumed meat and dairy had much poorer disability scores 624 (pTable 1. The frequency ofmultiple sclerosis disease activity was also significantly increased in meat and dairy consumers, 309% and 271% respectively (p Table 1: Level of disability and disease activity by dietary subgroups Soodeh Jahromi et al surveyed the diets of 75 women with multiple sclerosis from Iran. Dietary patterns were assessed using a 168-item food frequency questionnaire (FFQ). This study found patients whos diet consisted mainly of animal fat (high in animal fats, potato, other meat products, sugars, hydrogenated fats and low in whole grains, spices, and poultry without skin) had higher incidence of multiple sclerosis (OR = 1.99; CI: 1.63-2.94; P = 0.04), and patients who had a vegetable based diet (high in green leafy vegetables, hydrogenated fats, tomato, yellow vegetables, fruit juices, onion, and other vegetables) had lower incidence of multiple sclerosis. (OR = 0.42; 95% CI = 0.19-0.90; P = 0.026). These findings suggest an inverse relationship between high amount of hydrogenated fats, green leafy vegetables, fruit juices, and other vegetables and risk of multiple sclerosis. A longitudinal retrospective analysis was conducted by Weinstock-Guttman et al, where lipid levels of 492 multiple sclerosis patients were assessed for one a year time period. The study deduced that increasing LDL (p Geeta Ramsaransing et al investigated the levels of 23 dietary nutrients in 80 patients with multiple sclerosis: 27 with benign course multiple sclerosis, 32 with secondary progressive multiple sclerosis, and 21 with primary progressive multiple sclerosis. The secondary progressive group demonstrated significant decreases in magnesium intake (p In a cohort study by Mike Bogglid et al, 5583 multiple sclerosis patients in the UK were monitored from May 2002 to April 2005 in an effort to establish the long term cost effectiveness of current platform therapy (interferon-beta and/ or glatiramer acetate) for multiple sclerosis. Following the duration of the study, 49% of patients that were on platform therapy were found to have experienced progressive deterioration in EDSS 2.68 at baseline, 2.90 after one year, and 3.24 after two years (p Case Control Studies In a comparable study to Soodeh Jahromi et als work, a cross sectional analysis by Tatjana Pekmezomiv et al was conducted to investigate possible dietary trends in patients living with multiple sclerosis. The dietary habits of 110 multiple sclerosis patients were compared to 110 healthy controls. Results showed that meat intake such as chicken (OR=2.0, p=0.045), lamb (OR=2.1, p=0.013), and beef (OR=1.7, p=0.043) was significantly higher in multiple sclerosis patients as compared to healthy controls. Furthermore, the study found that multiple sclerosis patients consumed significantly higher levels of ice cream (OR=0.18, p=0.031) and butter (OR=1.7, p=0.056) in comparison to controls. Table 2 shows a brief summary of these results. These findings suggest that there is a significant association between dietary intake of meat products such as chicken, lamb, and beef, as well as ice cream and butter to the disease in question. This may suggest that removal or reduction of said food items may be beneficial in decreasing the incidence of multiple sclerosis. Table 2: Consumption frequency of different food groups and food items in MS patients and controls Fereshteh asharti et al conducted a case control study in order to evaluate cows milk allergy (CMA) in multiple sclerosis patients versus healthy individuals. The authors compared 48 multiple sclerosis patients with 48 healthy controls. After 16 weeks there were no differences in the frequency of CMA between the two groups. Contrary from the results of Emily Hadgkiss et als study, the study done by Vahid Shaygannejad et al, found that there was a higher frequency of dairy products consumed by healthy control individuals (67%, p=0.01) compared to multiple sclerosis patients. These findings suggest that there is no reliable association between milk consumption and risk of multiple sclerosis development. Discussion This review attempted to answer the question: Does diet modification significantly decrease the level of disability and improve the quality of life in patients suffering from multiple sclerosis? The general shared consensus of articles included in this review support the proposed hypothesis of diet modification can, indeed, significantly improve disability and quality of life in multiple sclerosis patients (Hadgkiss E et al., 2015; Jahromi S et al., 2012; Shaygannejad V et al., 2016; Yadav V et al., 2016; Ramsaransing G et al., 2009; Jahroomi S., 2012; Pekmezovic T et al., 2012). However, one article concluded that consumption of animal protein in the form of milk did not increase the risk of developing multiple sclerosis (Shaygannejad V et al., 2016). However, these findings should not be generalized to the general population as the sample size used was too small and did not represent a true spectrum of multiple sclerosis prevalence across the world. The remaining articles reviewed corroborated that removal of both animal based protein and saturated fatty acids from the diet, and their replacement, high starch, plant-based alternatives, provided improved disability and fatigue in patients suffering from this disease (Pekmezovic T et al., 2012; Yadav V et al., 2016). The plant based, high starch diet (potato and rice) was found not only be an efficacious treatment option for mitigating symptoms experienced by multiple sclerosis patients but is also economically accessible for all levels of society across the world. It is also evident that most clinicians involved in the articles reviewed, found enough evidence in their research to warrant providing advice to patients with multiple sclerosis about the importance of healthy diet modification in regards to their condition (Hadgkiss E et al., 2015; Jahromi S et al., 2012; Yadav V et al., 2016; Ramsaransing G et al., 2009;). Many of the articles reviewed used a survey platform to assess the diets of multiple sclerosis patients; this may have had some effect on the results due to the nature of the retrospective study design used, making way for possible recall bias, hence potential misreporting of dietary intake (Pekmezovic T et al., 2012; Hadgkiss, E et al., 2015;). As well, since many of the articles used a food frequency survey approach, it may have limited the interventions possible with regards to experimenting with different types of foods that may have improved or worsened multiple sclerosis outcomes. A common limitation in this review is that none of the articles inquired about portion sizes of their meals, just food items (Hadgkiss E et al., 2015; Jahromi S et al., 2012; Yadav V et al., 2016; Ramsaransing G et al., 2009; Jahroomi S., 2012;). Across all articles reviewed, mean age of the study population was between 30- 47 years; therefore the results of this review may not be true for younger or more elderly patients. Many of the researchers in this review found it difficult to recruit many subjects due to health concerns regarding a low protein diet (Hadgkiss E et al., 2015; Jahromi S et al., 2012; Yadav V et al., 2016; Ramsaransing G et al., 2009; Jahroomi S., 2012). It is possible that the results observed with regards to studying the diets of multiple sclerosis patients may have been due to associations with other confounding variables. It is also important to note that given the disabling nature of multiple sclerosis as a disease state, many of the patients may be relying on a caregiver or family member for their meals, which may influence their dietary intake. Limitations encountered in this review include only utilizing articles written within the past 10 years, articles collected from only two databases (PubMed and Google Scholar), and articles were only included only if they were published in the English language. Future research may consider standardizing meal portion sizes during experimentation as various parts of the world have varying standard portion sizes. Future studies should also consider accounting for possible supplementation use in the participants such as vitamin and mineral intake. This would help diminish possible confounding variable. Future research may also utilizing experimental analysis encompassing a larger age range. All together, these factors would help encompass a much broader spectrum of patients living with multiple sclerosis. Conclusion In conclusion, diet modification has been shown to be a viable option not only for effectively improving quality of life, and reducing disability in patients suffering from multiple sclerosis, but also in lowering the risk of developing the disease. Evidence showed that removal of both animal based protein and saturated fatty acids from the diet, and replacing them with plant-based alternatives which are high in starch showed noticeable improvement in muscle weakens and fatigue levels. Unfortunately we do not have sufficient research that definitively demonstrates that diet modification can be used alone without traditional medication to prevent and/ or treat multiple sclerosis. Additional studies are needed to assess the efficacy of dietary intervention with respect to reducing episodes of disability experienced by multiple sclerosis patients and including diet modification into the current disease modifying therapies available. References Ashtari, Fereshteh, Fatemeh Jamshidi, Raheleh Shokouhi Shoormasti, Zahra Pourpak, and Mojtaba Akbari. Cows milk allergy in multiple sclerosis patients. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences 18, no. Suppl 1 (2013): S62. PMCID: PMC3743324 Boggild, Mike., Palace, Jackie., Barton, Pelham., Ben-Shlomo, Y., Bregenzer, Thomas., Dobson, Charles., Gray, R. (2009). Multiple sclerosis risk sharing scheme: two year results of clinical cohort study with historical comparator. BMJ, 339, b4677. http://www.bmj.com/content/bmj/339/bmj.b4677.full.pdf. Browne, P., Chandraratna, D., Angood, C., Tremlett, H., Baker, C., Taylor, B. V., Thompson, A. J. (2014). Atlas of Multiple Sclerosis 2013: A growing global problem with widespread inequity. Neurology, 83(11), 1022-1024. http://doi.org/10.1212/WNL.0000000000000768 Guggenmos, Johannes, Anna S. Schubart, Sherry Ogg, Magnus Andersson, Tomas Olsson, Ian H. Mather, and Christopher Linington. Antibody cross-reactivity between myelin oligodendrocyte glycoprotein and the milk protein butyrophilin in multiple sclerosis. The Journal of Immunology 172, no. 1 (2004): 661-668. DOI: https://doi.org/10.4049/jimmunol.172.1.661 Emily J Hadgkiss, George A Jelinek, Tracey J Weiland, Naresh G Pereira, Claudia H Marck Dania M van der Meer (2015) The association of diet with quality of life, disability, and relapse rate in an international sample of people with multiple sclerosis, Nutritional Neuroscience, 18:3, 125-136, DOI: 10.1179/1476830514Y.0000000117 Evans, Charity, S-G. Beland, Sophie Kulaga, Christina Wolfson, Elaine Kingwell, James Marriott, Marcus Koch et al. Incidence and prevalence of multiple sclerosis in the Americas: a systematic review. Neuroepidemiology 40, no. 3 (2013): 195-210. doi: 10.1159/000342779. Jahroomi, Soode., Toghae, Mansoureh., Razeghu Jahromi, M., Aloosh, Mahdi. (2012). Dietary pattern and risk of multiple sclerosis. Iranian Journal of Neurology. 11(2), 47-53. PMCID: PMC3829243 Joscelyn, Jennifer., Kasper, Lloyde. H. (2014). Digesting the emerging role for the gut microbiome in central nervous system demyelination. Multiple Sclerosis Journal, 20 (12), 1553-1559. DOI: 10.1177/1352458514541579 Mà ¤hler, Anja, Jochen Steiniger, Markus Bock, Lars Klug, Nadine Parreidt, Mario Lorenz, Benno F. Zimmermann, Alexander Krannich, Friedemann Paul, and Michael Boschmann. Metabolic response to epigallocatechin-3-gallate in relapsing-remitting multiple sclerosis: a randomized clinical trial. The American journal of clinical nutrition 101, no. 3 (2015): 487-495. DOI: 10.3945/ajcn.113.075309 Otaegui, David, Sara Mostafavi, Claude CA Bernard, Adolfo Lopez de Munain, Parvin Mousavi, Jorge R. Oksenberg, and Sergio E. Baranzini. Increased transcriptional activity of milk-related genes following the active phase of experimental autoimmune encephalomyelitis and multiple sclerosis. The Journal of Immunology 179, no. 6 (2007): 4074-4082. doi: 10.4049/jimmunol.179.6.4074 Pekmezovic, Tatjana D., Darija B. Kisic Tepavcevic, Sarlota T. Mesaros, Irena B. Dujmovic Basuroski, Nebojsa S. Stojsavljevic, and Jelena S. Drulovic. Food and dietary patterns and multiple sclerosis: a case-control study in Belgrade (Serbia). Italian Journal of Public Health 6, no. 1 (2012). http://ijphjournal.it/article/view/5808 Ramsaransing, Geeta, Mellema, Sanne. A., De Keyser, J. (2009). Dietary patterns in clinical subtypes of multiple sclerosis: an exploratory study. Nutrition journal, 8(1), 36. DOI: 10.1186/1475-2891-8-36 Riccio, Paolo, and Rocco Rossano. Nutrition facts in multiple sclerosis. ASN neuro 7, no. 1 (2015): doi: 10.1177/1759091414568185 Riccio, Paolo., Rossano, Rocco., Liuzzi, G. Maria. (2011). May diet and dietary supplements improve the wellness of multiple sclerosis patients? A molecular approach. Autoimmune diseases, 2010. http://dx.doi.org/10.4061/2010/249842 Riccio, Paolo, Rocco Rossano, Marilena Larocca, Vincenzo Trotta, Ilario Mennella, Paola Vitaglione, Michele Ettorre et al. Anti-inflammatory nutritional intervention in patients with relapsing-remitting and primary-progressive multiple sclerosis: A pilot study. Experimental Biology and Medicine 241, no. 6 (2016): 620-635. DOI: 10.1177/1535370215618462 Shaygannejad, Vahid, Nooshin Rezaie, Zamzam Paknahad, Freshteh Ashtari, and Helia Maghzi. The environmental risk factors in multiple sclerosis susceptibility: A case-control study. Advanced Biomedical Research 5 (2016). doi: 10.4103/2277-9175.183665 Swank, R. L., and B. Brewer Dugan Effect of low saturated fat diet in early and late cases of multiple sclerosis. The Lanet 336, no. 8706(1990): 37-39. DOI:10.1016/0140-6736(90)91533 Tlaskalovà ¡-Hogenovà ¡, Helena, Renata Ã…Â  tĆºpà ¡nkovà ¡, Hana Kozà ¡kovà ¡, Tomà ¡Ãƒâ€¦Ã‚ ¡ Hudcovic, Luca Vannucci, Ludmila TuÄ kovà ¡, Pavel Rossmann et al. The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases. Cellular molecular immunology 8, no. 2 (2011): 110-120. http://www.nature.com/cmi/journal/v8/n2/abs/cmi201067a.html Vieira, Silvio. M., Pagovich, Odelya. E., Kriegel, Martin. A. (2014). Diet, microbiota and autoimmune diseases. Lupus, 23(6), 518-526. doi: 10.1177/0961203313501401 Weinstock-Guttman, Bianca, Robert Zivadinov, Naeem Mahfooz, Ellen Carl, Allison Drake, Jaclyn Schneider, Barbara Teter et al. Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis. Journal of neuroinflammation 8, no. 1 (2011): 127.DOI: 10.1186/1742-2094-8-127 Yadav, Vijayshree., Marracci, Gaild., Kim, Edward., Spain, Rebecca., Cameron, Michelle., Overs, Shanon., Murchison, C. (2016). Low-fat, plant-based diet in multiple sclerosis: A randomized controlled trial. Multiple Sclerosis and Related Disorders, 9, 80-90. DOI: 10.1016/j.msard.2016.07.001. Appendix First Author Population Year of Publication Study Design Outcome Ashtari, F. 48 patients with Multiple Sclerosis and 48 healthy patients as control group, mean age 30.7 March 18, 2013 Case control Study Serum IgE levels against cows milk antigen was taken from both groups. Results were very similar between both groups and showed no statistical significance (30.7  ± 6.9 vs. 30.9  ± 6.3 respectively, P value = 0.83) Boggild, M. 5583 patients with multiple sclerosis monitored from May 2002 to April 2005 from neurology clinics across the UK August 5, 2009 Prospective Cohort Study Patients received Interferon Beta treatment to determine long term cost effectiveness. Results showed worse disability progression than in the untreated group (deviation score of 113%; increase in mean disability status scale 0.28) Hadgkiss, E. 2087 patients with multiple sclerosis, mean age 45.5 participated in a comprehensive online survey March 17, 2014 Cross Sectional Study

jacksonian man of parts :: essays research papers

The recent International Poe conference saw a number of panels and individual presentations dedicated to examining the author’s works in their social and historical contexts, suggesting that contemporary Poe criticism is moving in a cultural direction long overlooked by scholars and critics. With no less than two full panels devoted specifically to issues of race in Poe’s writing, and other papers addressing issues of cultural identity, gender politics, Poe’s relationship to American literary nationalism, and the author’s ties to both antebellum society and Jacksonian democracy, this conference provided overwhelming evidence of a current desire to emplace Poe more specifically within his cultural and historical milieu. In a broader sense, such attention to the historical and cultural dynamics of Poe’s writing suggests increased attention of late to Poe’s own Americanness. This critical trend toward assessing Poe as a distinctly American writ er has, of course, also informed such excellent recent works as Terence Whalen’s Edgar Allan Poe and the Masses (1999) and the essays collected by Shawn Rosenheim and Stephen Rachman in The American Face of Edgar Allan Poe (1995). This paper represents an attempt to further such inquiry into the American â€Å"face† of Poe by examining the ways in which Poe’s unfortunately neglected tale â€Å"The Man that Was Used Up† complicates the author’s position in relation to American racial and national politics. One of Poe’s most biting satirical pieces, this tale raises vexing questions regarding the connections between matters of race, masculinity, and national identity as these concepts were imagined and constructed in Jacksonian America.   Ã‚  Ã‚  Ã‚  Ã‚  A minor tale in the canon of Poe’s short fiction, â€Å"The Man That Was Used Up† was first published in the August, 1839 issue of Burton’s Gentleman’s Magazine and subsequently revised and published twice more in Poe’s lifetime, first in Tales of the Grotesque and Arabesque (1840), and, finally, in the 9 August 1845 issue of the Broadway Journal. In this odd story, which chronicles the compromised stature of a military hero of the Indian Wars, Poe makes what would seem to be one of his most scathing, if indirect, commentaries on contemporary American politics. Specifically, the tale evokes the troubled relationship between the oppressive racial policies of the United States in the Age of Jackson and the burgeoning sense of national purpose and unity embodied in the figure of the robust, heroic, Jacksonian â€Å"self-made man.† Composed at a time when the United States was embroiled in the Second Seminole War (1835-42), am ong the longest and costliest of the Indian Wars, the story positions its central figure, Brevet Brigadier General John A.

The Great White Father Myth - A Hypocritical Belief :: Synthesis Essays

The Great White Father Myth - A Hypocritical Belief  Ã‚  Ã‚     Ã‚  Ã‚   In the informative article "The Great White Father Myth," the author Stan Steiner discusses the stereotypical view that the white man has created of himself as the hero, conqueror, and savior. He labels this view as "The Great White Father Myth," and begins by talking about the silent role the Indians have taken in the face of their Great White Father. Steiner supports his view of the white man's superiority as being nothing more than a myth, by discussing the crimes the white man committed against the Indians were silenced. The Indian Wars and the White man's desire to civilize the Indians were illustrations of the myth that whites were superior. Although the article contains a one-sided view of the events between the Europeans and the Indians, the fact that the white man is hypocritical in the view of himself as the Great White Father comes through very accurately and strongly. This idea is shown very evidently even though Steiner never comes out and defines what the Great White Father Myth is. He shows what he means through examples. Basically, through illustrations he shows that he feels the myth is that whites are superior beings of the human race. This created identity makes their values, religion, and culture the ideal goal for other races to follow. Since the white race is the "father" it is his duty to punish and change anyone who is different. In "An Indian Story of the Sierra Madre," the typical white hero and savior image of the Great White Father Myth that Steiner describes comes through. Captain Ben, who is the white cowboy hero, knows everything. In the beginning, he knows that the Indians are near just by looking at some birds over head. In his mind, Ben knows without even seeing them that they want to kill him and his men. As a result of this conclusion, smart Ben devises a scheme to kill the Indians and saves the day. After the massacre, he finds money with the Indians and knows automatically that they stole it. Captain Ben, being the savior and all around good guy, recovers the money and intends to find its owner and return it. The story continues in this same stereotypical fashion (DeQuille 242). This is how the white man pictures himself in comparison to the Indian: white = good and red skin = bad.

How important is that we are certain about what we claim as knowledge? Essay

How important is that we are certain about what we claim as knowledge? According to my opinion, it is crucial to identify what we claim as knowledge. The world has a lot of information but not all of them can be claimed as knowledge that is suitable to. Everything from your opinion to the life changing decisions you make are dependent on the knowledge that you identify as your own through your own perspectives and also through your experiences. To me, unnecessary knowledge is something a person does not have to have and does not need to be claimed by a person. To distinguish between necessary and unnecessary knowledge one must know what he or she believes in and would need to be steadfast to that topic. By doing this your knowledge will be refined, rather than flooded. By saying this, it does not mean that the knowledge you can collect should not be collected it is just that the knowledge that is refined to your stature is definitely going to help you better than any other knowledge that you collect that does not come under your scope. The importance of what we claim as knowledge differs from person to person and in the end the basic background and culture the person is from, will determine what knowledge he identifies and adores. All in all the knowledge that you have does not merely state what you know, it describes what kind of a person you are and how your life has been and will be! How important is that we are certain about what we claim as knowledge? According to my opinion, it is crucial to identify what we claim as knowledge. The world has a lot of information but not all of them can be claimed as knowledge that is suitable to. Everything from your opinion to the life changing decisions you make are dependent on the knowledge that you identify as your own through your own perspectives and also through your experiences. To me, unnecessary knowledge is something a person does not have to have and does not need to be claimed by a person. To distinguish between necessary and unnecessary knowledge one must know what he or she believes in and would need to be steadfast to that topic.

Foundation and Empire 15. The Psychologist

There was reason to the fact that the element known as â€Å"pure science† was the freest form of life on the Foundation. In a Galaxy where the predominance – and even survival – of the Foundation still rested upon the superiority of its technology – even despite its large access of physical power in the last century and a half – a certain immunity adhered to The Scientist. He was needed, and he knew it. Likewise, there was reason to the fact that Ebling Mis – only those who did not know him added his titles to his name – was the freest form of life in the â€Å"pure science† of the Foundation. In a world where science was respected, he was The Scientist – with capital letters and no smile. He was needed, and he knew it. And so it happened, that when others bent their knee, he refused and added loudly that his ancestors in their time bowed no knee to any stinking mayor. And in his ancestors' time the mayor was elected anyhow, and kicked out at will, and that the only people that inherited anything by right of birth were the congenital idiots. So it also happened, that when Ebling Mis decided to allow Indbur to honor him with an audience, he did not wait for the usual rigid line of command to pass his request up and the favored reply down, but, having thrown the less disreputable of his two formal jackets over his shoulders and pounded an odd hat of impossible design on one side of his head, and lit a forbidden cigar into the bargain, he barged past two ineffectually bleating guards and into the mayor's palace. The first notice his excellence received of the intrusion was when from his garden he heard the gradually nearing uproar of expostulation and the answering bull-roar of inarticulate swearing. Slowly, Indbur lay down his trowel; slowly, he stood up; and slowly, he frowned. For Indbur allowed himself a daily vacation from work, and for two hours in the early afternoon, weather permitting, he was in his garden. There in his garden, the blooms grew in squares and triangles, interlaced in a severe order of red and yellow, with little dashes of violet at the apices, and greenery bordering the whole in rigid lines. There in his garden no one disturbed him – no one! Indbur peeled off his soil-stained gloves as he advanced toward the little garden door. Inevitably, he said, â€Å"What is the meaning of this?† It is the precise question and the precise wording thereof that has been put to the atmosphere on such occasions by an incredible variety of men since humanity was invented. It is not recorded that it has ever been asked for any purpose other than dignified effect. But the answer was literal this time, for Mis's body came plunging through with a bellow, and a shake of a fist at the ones who were still holding tatters of his cloak. Indbur motioned them away with a solemn, displeased frown, and Mis bent to pick up his ruin of a hat, shake about a quarter of the gathered dirt off it, thrust it under his armpit and say: â€Å"Look here, Indbur, those unprintable minions of yours will be charged for one good cloak. Lots of good wear left in this cloak.† He puffed and wiped his forehead with just a trace of theatricality. The mayor stood stiff with displeasure, and said haughtily from the peak of his five-foot-two, â€Å"It has not been brought to my attention, Mis, that you have requested an audience. You have certainly not been assigned one.† Ebling Mis looked down at his mayor with what was apparently shocked disbelief, â€Å"Ga-LAX-y, Indbur, didn't you get my note yesterday? I handed it to a flunky in purple uniform day before. I would have handed it to you direct, but I know how you like formality.† â€Å"Formality!† Indbur turned up exasperated eyes. Then, strenuously, â€Å"Have you ever heard of proper organization? At all future times you are to submit your request for an audience, properly made out in triplicate, at the government office intended for the purpose. You are then to wait until the ordinary course of events brings you notification of the time of audience to be granted. You are then to appear, properly clothed – properly clothed, do you understand – and with proper respect, too. You may leave.† â€Å"What's wrong with my clothes?† demanded Mis, hotly. â€Å"Best cloak I had till those unprintable fiends got their claws on it. I'll leave just as soon as I deliver what I came to deliver. â€Å"Ga-LAX-y, if it didn't involve a Seldon Crisis, I would leave right now.† â€Å"Seldon crisis!† Indbur exhibited first interest. Mis was a great psychologist – a democrat, boor, and rebel certainly, but a psychologist, too. In his uncertainty, the mayor even failed to put into words the inner pang that stabbed suddenly when Mis plucked a casual bloom, held it to his nostrils expectantly, then flipped it away with a wrinkled nose. Indbur said coldly, â€Å"Would you follow me? This garden wasn't made for serious conversation.† He felt better in his built-up chair behind his large desk from which he could look down on the few hairs that quite ineffectually hid Mis's pink scalp-skin. He felt much better when Mis cast a series of automatic glances about him for a non-existent chair and then remained standing in uneasy shifting fashion. He felt best of all when in response to a careful pressure of the correct contact, a liveried underling scurried in, bowed his way to the desk, and laid thereon a bulky, metal-bound volume. â€Å"Now, in order,† said Indbur, once more master of the situation, â€Å"to make this unauthorized interview as short as possible, make your statement in the fewest possible words.† Ebling Mis said unhurriedly, â€Å"You know what I'm doing these days?† â€Å"I have your reports here,† replied the mayor, with satisfaction, â€Å"together with authorized summaries of them. As I understand it, your investigations into the mathematics of psychohistory have been intended to duplicate Hari Seldon's work and, eventually, trace the projected course of future history, for the use of the Foundation.† â€Å"Exactly,† said Mis, dryly. â€Å"When Seldon first established the Foundation, he was wise enough to include no psychologists among the scientists placed here – so that the Foundation has always worked blindly along the course of historical necessity. In the course of my researches, I have based a good deal upon hints found at the Time Vault.† â€Å"I am aware of that, Mis. It is a waste of time to repeat.† â€Å"I'm not repeating,† blared Mis, â€Å"because what I'm going to tell you isn't in any of those reports.† â€Å"How do you mean, not in the reports?† said Indbur, stupidly. â€Å"How could-â€Å" â€Å"Ga-LAX-y, Let me tell this my own way, you offensive little creature. Stop putting words into my mouth and questioning my every statement or I'll tramp out of here and let everything crumble around you. Remember, you unprintable fool, the Foundation will come through because it must, but if I walk out of here now – you won't.† Dashing his hat on the floor, so that clods of earth scattered, he sprang up the stairs of the dais on which the wide desk stood and shoving papers violently, sat down upon a comer of it. Indbur thought frantically of summoning the guard, or using the built-in blasters of his desk. But Mis's face was glaring down upon him and there was nothing to do but cringe the best face upon it. â€Å"Dr. Mis,† he began, with weak formality, â€Å"you must-â€Å" â€Å"Shut up,† said Mis, ferociously, â€Å"and listen. If this thing here,† and his palm came down heavily on the metal of the bound data, â€Å"is a mess of my reports – throw it out. Any report I write goes up through some twenty-odd officials, gets to you, and then sort of winds down through twenty more. That's fine if there's nothing you don't want kept secret. Well, I've got something confidential here. It's so confidential, even the boys working for me haven't got wind of it. They did the work, of course, but each just a little unconnected piece – and I put it together. You know what the Time Vault is?† Indbur nodded his head, but Mis went on with loud enjoyment of the situation, â€Å"Well, I'll tell you anyhow because I've been sort of imagining this unprintable situation for a â€Å"Ga-LAX-y, of a long time; I can read your mind, you puny fraud. You've got your hand right near a little knob that'll call in about five hundred or so armed men to finish me off, but you're afraid of what I know – you're afraid of a Seldon Crisis. Besides which, if you touch anything on your desk, I'll knock your unprintable head off before anyone gets here. You and your bandit father and pirate grandfather have been blood-sucking the Foundation long enough anyway.† â€Å"This is treason,† gabbled Indbur. â€Å"It certainly is,† gloated Mis, â€Å"but what are you going to do about it? Let me tell you about the Time Vault. That Time Vault is what Hari Seldon placed here at the beginning to help us over the rough spots. For every crisis, Seldon has prepared a personal simulacrum to help – and explain. Four crises so far – four appearances. The first time he appeared at the height of the first crisis. The second time, he appeared at the moment just after the successful evolution of the second crisis. Our ancestors were there to listen to him both times. At the third and fourth crises, he was ignored – probably because he was not needed, but recent investigations – not included in those reports you have – indicate that he appeared anyway, and at the proper times. Get it?† He did not wait for any answer. His cigar, a tattered, dead ruin was finally disposed of, a new cigar groped for, and lit. The smoke puffed out violently. He said, â€Å"Officially I've been trying to rebuild the science of psychohistory. Well, no one man is going to do that, and it won't get done in any one century, either. But I've made advances in the more simple elements and I've been able to use it as an excuse to meddle with the Time Vault. What I have done, involves the determination, to a pretty fair kind of certainty, of the exact date of the next appearance of Hari Seldon. I can give you the exact day, in other words, that the coming Seldon Crisis, the fifth, will reach its climax. â€Å" â€Å"How far off?† demanded Indbur, tensely. And Mis exploded his bomb with cheerful nonchalance, â€Å"Four months,† he said. â€Å"Four unprintable months, less two days.† â€Å"Four months,† said Indbur, with uncharacteristic vehemence. â€Å"Impossible.† â€Å"Impossible, my unprintable eye.† â€Å"Four months? Do you understand what that means? For a crisis to come to a head in four months would mean that it has been preparing for years.† â€Å"And why not? Is there a law of Nature that requires the process to mature in the full light of day?† â€Å"But nothing impends. Nothing hangs over us.† Indbur almost wrung his hands for anxiety. With a sudden spasmodic recrudescence of ferocity, he screamed, â€Å"Will you get off my desk and let me put it in order? How do you expect me to think?† Mis, startled, lifted heavily and moved aside. Indbur replaced objects in their appropriate niches with a feverish motion. He was speaking quickly, â€Å"You have no right to come here like this. If you had presented your theory-â€Å" â€Å"It is not a theory.† â€Å"I say it is a theory. If you had presented it together with your evidence and arguments, in appropriate fashion, it would have gone to the Bureau of Historical Sciences. There it could have been properly treated, the resulting analyses submitted to me, and then, of course, proper action would have been taken. As it is, you've vexed me to no purpose. Ah, here it is.† He had a sheet of transparent, silvery paper in his hand which he shook at the bulbous psychologist beside him. â€Å"This is a short summary I prepare myself – weekly – of foreign matters in progress. Listen – we have completed negotiations for a commercial treaty with Mores, continue negotiations for one with Lyonesse, sent a delegation to some celebration or other on Bonde, received some complaint or other from Kalgan and we've promised to look into it, protested some sharp trade practices in Asperta and they've promised to look into it – and so on and so on.† The mayor's eyes swarmed down the list of coded notations, and then he carefully placed the sheet in its proper place in the proper folder in the proper pigeonhole. I tell you, Mis, there's not a thing there that breathes anything but order and peace-â€Å" The door at the far, long end opened, and, in far too dramatically coincident a fashion to suggest anything but real life, a plainly-costumed notable stepped in. Indbur half-rose. He had the curiously swirling sensation of unreality that comes upon those days when too much happens. After Mis's intrusion and wild fumings there now came the equally improper, hence disturbing, intrusion unannounced, of his secretary, who at least knew the rules. The secretary kneeled low. Indbur said, sharply, â€Å"Well!† The secretary addressed the floor, â€Å"Excellence, Captain Han Pritcher of Information, returning from Kalgan, in disobedience to your orders, has according to prior instructions – your order X20-513 – been imprisoned, and awaits execution. Those accompanying him are being held for questioning. A full report has been filed.† Indbur, in agony, said, â€Å"A full report has been received. Well!† â€Å"Excellence, Captain Pritcher has reported, vaguely, dangerous designs on the part of the new warlord of Kalgan. He has been given, according to prior instructions – your order X20-651 – no formal hearing, but his remarks have been recorded and a full report filed.† Indbur screamed, â€Å"A full report has been received. Well!† â€Å"Excellence, reports have within the quarter-hour been received from the Salinnian frontier. Ships identified as Kalganian have been entering Foundation territory, unauthorized. The ships are armed. Fighting has occurred.† The secretary was bent nearly double. Indbur remained standing. Ebling Mis shook himself, clumped up to the secretary, and tapped him sharply on the shoulder. â€Å"Here, you'd better have them release this Captain Pritcher, and have him sent here. Get out.† The secretary left, and Mis turned to the mayor, â€Å"Hadn't you better get the machinery moving, Indbur? Four months, you know.† Indbur remained standing, glaze-eyed. Only one finger seemed alive – and it traced rapid jerky triangles on the smooth desk top before him.